Ibutamoren is among the most recent products to hit SARMs shelves.
Like SARMs, Ibutamoren shows incredible performance enhancement benefits.
However, before you try out any product, it is important to know what you are getting yourself into.
In this review, we shall discuss Ibutamoren. What it is all about, and whether it is safe to use. Read on.
Table of Contents
What is Ibutamoren (MK 677)
This compound goes by many names, including Ibutamoren, Ibutamoren Mesylate, MK 677, and Nutrabol.
Ibutamoren is a non-peptide agonist of ghrelin. As such, it is a growth hormone secretagogue. Ghrelin, also known as the hunger hormone, is responsible for critical processes such as regulating homeostasis, energy, and body weight.
More importantly, however, ghrelin stimulates the pituitary gland to secrete the growth hormone (GH). Any substance that stimulates the secretion of GH is a growth hormone secretagogue.
Being an agonist of ghrelin means that MK 677 mimics the effects of ghrelin, especially as a growth hormone secretagogue.
Findings from studies reveal that Ibutamoren significantly increases the production of GH, as well as the insulin-like growth factor 1, resulting in effects such as an increase in lean muscle mass. Other studies reveal that Ibutamoren also helps to increase bone mineral density, thereby making it a potential solution in the treatment of frailty in senior citizens.
Thanks to those findings, MK 677 is still undergoing clinical trials as a potential treatment for growth hormone deficiency in both kids and adults. It is actually in the preclinical stage of development as a treatment for growth hormone deficiency.
Nonetheless, despite all these findings, Ibutamoren is still an investigational drug, meaning that it is yet to be cleared for human consumption. However, you can legally purchase it for ‘research’ purposes.
What Does Ibutamoren MK 677 Do?
As mentioned, MK 677 is an agonist of ghrelin, meaning that it mimics the effects of ghrelin. One of those effects is stimulating the pituitary gland to secrete more growth hormone.
An increase in growth hormone (GH) secretion results in several wholesome benefits. GH is responsible for the growth, reproduction, and regeneration of cells in the body. Additionally, GH also actively helps in the building, repair, and maintenance of tissues.
Therefore, having more GH in your body means that the rate at which your muscle tissue recovers from a workout or injury becomes enhanced greatly. Consequently, you will build muscle mass at a much faster rate. An increase in GH also means a boost in metabolism, thus increasing the rate at which you burn fat.
GH also stimulates the liver to release an insulin-like protein that helps in the production of cartilage cells. These cells play a critical role in the formation and growth of bones and organs and in muscle synthesis as well. Since your skin is also an organ, an increase in GH means that it will become suppler as well.
This is why GH is considered an anti-aging hormone, as it not only makes you feel younger but also look younger.
By mimicking the actions of ghrelin, MK 677 also improves your cognitive functions, mood, and biological rhythms.
While Ibutamoren has an effect on your brain functions, the good news is that it does not affect cortisol levels. Cortisol is a hormone that the brain releases when you are under stress. This is why it is known as the “stress hormone.”
An increase in cortisol levels is associated with several undesirable effects, such as muscle wasting, an increase in body fat, poor immunity, reduced healing ability, and poor cognitive functioning.
What are Some MK 677 Benefits?
So far, you already know that taking Ibutamoren can result in a boatload of benefits. Let us look at each of those benefits in more detail:
i) Increase in Lean Muscle Mass
Ibutamoren promotes lean muscle tissue development using two mechanisms. First off, it stimulates the pituitary gland into secreting more growth hormone. The second is by signaling your liver to release more insulin-like growth factor 1 (IGF-1).
GH and IGF-1 work togetherto not only boost the rate of protein synthesis but also your strength, as well thanks to the subsequent increase in energy levels.
Protein synthesis is the process through which the body uses amino acids to create protein molecules. Protein, on the other hand, is the primary building block of muscles.
For muscle growth to occur, you must first create micro-tears in your muscle tissue, after which the body utilizes protein to repair the damage. The result is a bigger and stronger muscle.
GH and IGF-1 also enhance the rate at which you recover from hard workouts, thus allowing you to train hard for longer. Additionally, they improve your nitrogen retention capacity. Nitrogen is the main building block for amino acids. Therefore, more nitrogen means more protein in your system.
All this means that MK 677 works to create a muscle-building environment inside the body.
ii) Preventing Muscle Wastage
MK 677 also helps to prevent muscle catabolism, which is the process through which the body breaks down muscle tissue for protein to use as energy during periods of starvation, or when one is not getting enough protein in their diet.
It does this by increasing your nitrogen retention capacity, as well as improving the rate at which you synthesize protein.
In a double-blind, placebo-controlled, two-period, randomized study, it was observed that Ibutamoren helped to prevent muscle wastage by reversing protein loss.
iii) Promoting Fat Loss
Studies reveal that there is a direct correlation between being overweight and low levels of GH. By increasing your GH levels, therefore, you will increase the rate at which you burn fat and lose weight.
GH promotes fat loss through its actions on the enzymes that control lipolysis and lipogenesis. Lipolysis is the process through which stored triglycerides are broken down into free fatty acids. The lipoprotein (LPL) enzyme controls this process. Lipogenesis, on the other hand, is the process through which the body accumulates fat, and it is controlled by the hormone-sensitive lipase (HSL) enzyme.
GH prevents fat storage by first reducing the absorption of free fatty acids (FFAs) by the fat storage cells (adipocytes). It does that by inhibiting the actions of LPL since less LPL means a reduced number of fatty acids being stored as fat. GH also encourages your body to use free fatty acids as energy, thus further reducing the amount of FFAs being stored. In fact, studies show that elevated levels of free fatty acids in obese individuals is part of the reason why they have low GH levels.
Hormone-sensitive lipase (HSL) is an enzyme that encourages fat burning, thereby controlling the rate at which you accumulate fat. Therefore, one of the best ways of promoting fat loss is by increasing the activity of HSL. According to studies, the growth hormone potentiates the effects of HSL, thus leading to an increased rate of fat burning.
iv) Increased Bone Density
As mentioned earlier, findings from studies reveal that using MK 677 can result in increased bone mineral density.
As an athlete, this is definitely something you want since you are constantly putting your bones through stress, especially if running is an activity that you are constantly doing.
Overweight individuals could also benefit massively from an increased bone density as the extra weight that they carry around causes stress on their underlying skeletal structure. Studies reveal that the mechanical overloading on bones from excess body weight predisposes them to fracturing. Additionally, being overweight has been shown to compromise bone quality. Therefore, by supplementing Ibutamoren, obese or overweight individuals can reduce their susceptibility to bone disease.
The other group that will benefit tremendously from increased bone density are the elderly. According to studies, we lose bone density or mass as we age. For women, this change becomes especially apparent after menopause. This is what usually leads to frailty among the elderly. Fortunately, this effect can be reversed by increasing GH levels in the body, as studies show that the growth hormone has an anabolic effect on bones, resulting in increased bone turnover, as well as bone mineral density.
v) Treating Growth Hormone Deficiency
Due to its ability to increase growth hormone levels in the body. MK 677 is being evaluated as a potential treatment for growth hormone deficiency.
MK 677 for Bodybuilding: Is it Effective?
As mentioned, Ibutamoren creates the ideal environment in the body for muscle growth by increasing GH and IGF-1 levels in the body. Increased GH and IGF-1 levels result in effects such as an increased rate of protein synthesis, increased nitrogen retention capacity, faster recovery from workouts, and higher overall energy levels.
With higher energy levels, you can train hard for longer. A fast muscle recovery rate means that you will not be prone to soreness that typically follows intense workouts, thus allowing you to go hard more frequently. As a result, your muscles tear and rebuild rapidly, which is the effect you want when looking to add muscle mass.
An increased rate of protein synthesis comes in handy when the muscle is rebuilding from a hard workout. Your muscles use protein to build tissue. As such, the faster you can synthesize protein, the faster muscle building can take place.
Therefore, MK 677 is indeed effective for bodybuilding.
How to Take MK 677
Since Ibutamoren is still an investigational drug, there are no official dosage guidelines on how to take this drug. As such, all dosage guidelines on MK 677 are based on anecdotal reports.
With that said, it appears that a dose of between 10 – 25 mg is what is optimal for most people. Ibutamoren has a half-life of 24 hours. Half-life refers to the duration where the dose is still active in your system.
This means that regardless of when you take your MK 677 Nutrabol dose, your GH levels will be elevated for the next 24 hours. When it comes to MK 677 dosage times, it is recommended that you either take the dose at night before you sleep or you split the dose into two and take half in the morning and the other half in the evening.
This is because Ibutamoren tends to cause a severe energy crash after a while. Therefore, by taking it at night, you will not have to worry about that crash, as you will be asleep. On the other hand, by splitting your dose, you will be reducing the severity of the crash.
MK 677 Cycle Length
The optimal Ibutamoren cycle lasts between 10 and 12 weeks. Take four weeks off before resuming your cycle.
MK 677 Before and After Customer Reviews
After scouring the web for user experiences with MK 677, the vast majority we found were overwhelmingly positive: John, for instance, had this to say.
Ibutamoren Side Effects
While most people can use MK 677 safely over the long term, this compound comes with the risk of certain side effects depending on specific circumstances.
For example, when getting started, it is recommended that you begin with the smallest dose possible (10 mg) to allow your body to get accustomed to the new substance. Taking a high dose at the get-go can result in undesirable effects such as increased appetite, edema, and muscle cramps. Fortunately, these effects stop manifesting with time.
A prevalent side effect of Ibutamoren, however, is the fatigue or energy crash that it causes. Fortunately, you can work around this effect by timing your dose, so you take it at night. When you do that, you turn that side effect into a benefit as it lulls you into a deep sleep.
MK 677 might not be appropriate for certain groups of people. For example, if you are predisposed to insulin issues, this compound can reduce your insulin sensitivity while raising your blood glucose and pressure levels.
Therefore, ensure to consult a doctor before you take this supplement.
Where to Buy MK 677
As mentioned, Ibutamoren is typically put in the same category as SARMs, as they both serve the same purpose. As such, the first place you should consider when looking for MK 677 is at a SARMs vendor.
Nonetheless, you have to research a vendor first before buying from them. This is because the market is full of unscrupulous stores selling counterfeit products. Simply search “MK 677 for sale” on Google, and then start evaluating the options.
Once you identify a MK 677 vendor, visit SARMs forums to see what other consumers think about them. For example, you could simply search “Is X legit?”.
Is MK 677 Legal?
Here is the thing you can buy or sell MK 677 legally, but only as a research chemical. This is because it is yet to be declared as fit for human consumption.
Nonetheless, you will never get into legal trouble for having this product in your possession. However, if asked, say that you have it for “research purposes.”
Verdict: Does Mk 677 Work?
If the numerous studies done on this compound, as well as anecdotal reports, are anything to go by, MK 677 is the real deal.
Can We Use MK 677 for Women?
Yes, women can use Ibutamoren. Unlike steroids, MK 677 does not affect levels of your sex hormones i.e., estrogen and testosterone. Instead, it helps you build muscle or burn fat by increasing levels of GH. In fact, women should find MK 677 quite useful, as their GH levels tend to reduce at significantly faster than those of men.
What is MK 677 Price?
This will vary from vendor to vendor; however, the average price is $49.99 for a 750 mg bottle. If you are taking 25 mg per day, such a bottle will last you a month. Therefore, for a 12-week cycle, you might spend about $150.00.
How Much Ibutamoren Should I Take?
The recommended MK 677 dose is between 10 and 25 mg per day. Start with 10 and make your way up gradually.
How Long Will it Take to See Results from Ibutamoren?
While you will experience the effects of having higher GH levels almost immediately, it might take up to two weeks for your physique to start showing changes.
Is Ibutamoren Sold Over the Counter?
Online SARMs vendors typically sell Ibutamoren. However, if a vendor has a physical store near you, they might sell it over-the-counter, even though it is highly unlikely.
Is Ibutamoren a Nootropic?
Since MK 677 mimics the effects of ghrelin, it does have cognitive-enhancing properties. However, it might not be as powerful as other nootropics on the market.
Can I Use Ibutamoren and Ostarine Together?
If the goal is to add lean muscle mass, this is a recommended combination, as they both work towards that goal.